Article
Frequent somatic imbalance of marker alleles for chromosome 1 in human primary breast carcinoma.
Cancer research - 1 Feb 1991
Devilee P, van Vliet M, Bardoel A, Kievits T, Kuipers-Dijkshoorn N, Pearson P L, Cornelisse C J
Abstract excerpt
Loss of heterozygosity at particular chromosomal loci in the tumor cell, as evidenced by restriction fragment length polymorphism analysis, has been taken as a hallmark of the presence of tumor suppressor genes. Recent studies of breast carcinoma have suggested that such genes might be located on the short as well as on the long arm of chromosome 1. We report here that comparison of constitutional and tumor...
Topics
- Alleles
- Breast Neoplasms
- Chromosome Mapping
- Chromosomes, Human, Pair 1
- Genetic Markers
- Genotype
- Humans
- Polymorphism, Restriction Fragment Length