Article
Quinidine inhibition of debrisoquine S(+)-4- and 7-hydroxylations in Chinese of different CYP2D6 genotypes.
Pharmacogenetics - 1 Apr 1993
Bertilsson L, Meese C O, Yue Q Y, Dahl M L, Ingelman-Sundberg M, Johansson I, Säwe J, Eichelbaum M
Abstract excerpt
Pronounced differences in the CYP2D6 gene between Chinese and Caucasians have previously been described. There was a low frequency of detrimental mutations in the Chinese CYP2D6 gene causing the poor metabolizer (PM) phenotype. In contrast to Caucasians where the Xba I 44 kb allele is almost always associated with the PM phenotype, Chinese with the 44/44 kb RFLP pattern are extensive metabolizers (EM). In order...
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