Article
Quinidine inhibition of debrisoquine S(+)-4- and 7-hydroxylations in Chinese of different CYP2D6 genotypes.
Pharmacogenetics - 1 Apr 1993
Bertilsson L, Meese C O, Yue Q Y, Dahl M L, Ingelman-Sundberg M, Johansson I, Säwe J, Eichelbaum M
Abstract excerpt
Pronounced differences in the CYP2D6 gene between Chinese and Caucasians have previously been described. There was a low frequency of detrimental mutations in the Chinese CYP2D6 gene causing the poor metabolizer (PM) phenotype. In contrast to Caucasians where the Xba I 44 kb allele is almost alwa...
Topics
- Asian People
- Cytochrome P-450 CYP2D6
- Cytochrome P-450 Enzyme Inhibitors
- Cytochrome P-450 Enzyme System
- Debrisoquin
- Genotype
- Haplotypes
- Humans
- Hydroxylation
- Metabolic Clearance Rate
- Mixed Function Oxygenases
- Polymorphism, Restriction Fragment Length
- Quinidine
- Stereoisomerism
- White People