Article
Somatic APC and K-ras codon 12 mutations in periampullary adenomas and carcinomas from familial adenomatous polyposis patients.
Oncogene - 4 May 1995
Gallinger S, Vivona A A, Odze R D, Mitri A, O'Beirne C P, Berk T C, Bapat B V
Abstract excerpt
Periampullary adenomas in the duodenum of Familial Adenomatous Polyposis (FAP) patients are among the most frequent and clinically important extracolonic neoplasms in FAP. The purpose of this study was to characterize the frequency and nature of somatic adenomatous polyposis coli (APC) gene and K-ras codon 12 mutations in periampullary adenomas and carcinomas in FAP. These molecular changes have been shown to be...
Topics
- Adenoma
- Adenomatous Polyposis Coli
- Base Sequence
- Carcinoma
- Colonic Neoplasms
- DNA Primers
- Genes, APC
- Genes, ras
- Humans
- Molecular Sequence Data
- Mutation