Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Frequent incidence of somatic mutations in translocated BCL2 oncogenes of non-Hodgkin's lymphomas.

Blood - 1 Jan 1992

Tanaka S, Louie D C, Kant J A, Reed J C

Abstract excerpt

The majority of non-Hodgkin's B-cell lymphomas contain a t(14;18) translocation that places the bc12 gene into juxtaposition with the transcriptically active Ig heavy-chain locus, thus deregulating the expression of this proto-oncogene. The bc12 gene product is a membrane-associated mitochondrial protein that regulates cell survival through unknown mechanisms. Although overproduction of the normal protein appears...

Topics

Base Sequence
Chromosomes, Human, Pair 14
Chromosomes, Human, Pair 18
DNA, Neoplasm
Humans
Lymphoma, Non-Hodgkin
Molecular Sequence Data
Mutation
Polymerase Chain Reaction
Proto-Oncogene Mas
Proto-Oncogene Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Proto-Oncogene Proteins c-bcl-2

Translocation, Genetic

Tumor Cells, Cultured

Source

Identifiers

PMID: 1339299

Genes

BCL2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1339299-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Frequent incidence of somatic mutations in translocated BCL2 oncogenes of non-Hodgkin's lymphomas.PMID 1339299Read ↗

Somatic point mutations in the translocated bcl-2 genes of non-Hodgkin's lymphomas and lymphocytic leukemias: implications for mechanisms of tumor progression.Semantic proximity Read ↗

Infrequent BCL10 mutations in B-cell non-Hodgkin's lymphomas.Semantic proximity Read ↗

Analysis of BCL-6 mutations in classic Hodgkin disease of the B- and T-cell type.Semantic proximity Read ↗

Application of a PCR-mismatch technique to the BCL-2 gene: detection of point mutations in BCL-2 genes of malignancies with A t(14,18).Semantic proximity Read ↗

Chromosomal Abnormalities in Patients With Hodgkin's Disease: Evidence for Frequent Involvement of the 14q Chromosomal Region but Infrequent bcl-2 Gene Rearrangement in Reed-Sternberg CellsSemantic proximity Read ↗

Hematopoietic malignancies demonstrate loss-of-function mutations of BAX.Semantic proximity Read ↗

The bcl-2 gene and protein in malignant lymphomas.Semantic proximity Read ↗

Altered nucleotide sequences of a translocated c-myc gene in Burkitt lymphoma.Semantic proximity Read ↗

Clustered mutations in the second exon of the MYC gene in sporadic Burkitt's lymphoma.Semantic proximity Read ↗

p53 Mutations, c-myc and bcl-2 Rearrangements in Human Non-Hodgkin's Lymphoma Cell LinesSemantic proximity Read ↗

All Patients with Persistent Polyclonal B Cell Lymphocytosis Present Bcl-2/Ig Gene RearrangementsSemantic proximity Read ↗

Infrequent bax gene mutations in B-cell lymphomas.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.