Chromosomal Abnormalities in Patients With Hodgkin's Disease: Evidence for Frequent Involvement of the 14q Chromosomal Region but Infrequent bcl-2 Gene Rearrangement in Reed-Sternberg Cells

Abstract excerpt

BACKGROUND: Rearrangements of the bcl-2 gene (also known as BCL2) have been detected in up to 40% of cases of Hodgkin's disease, and it has been speculated that such rearrangements may have a role in the pathogenesis of Hodgkin's disease. PURPOSE: The purposes of this study were (a) to assess the frequency of clonal chromosomal abnormalities in Hodgkin's disease, (b) to identify recurrent changes, (c) to...

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