Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

All Patients with Persistent Polyclonal B Cell Lymphocytosis Present Bcl-2/Ig Gene Rearrangements

1 Jan 1998

Abstract excerpt

The bcl-2 gene belongs to a class of oncogenes involved in the inhibition of apoptosis. Most follicular lymphomas are associated with the t(14;18) translocation that juxtaposes the bcl-2 gene located on chromosome 18 to the immunoglobulin gene locus located on chromosome 14. Consequently, the bcl-2 gene is overly expressed and leads to an accumulation of mature clonal B cells. Prolonged survival of the B cell...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Blood groups and transfusion
Share to Chronic Lymphocytic Leukemia Research
Share to Monoclonal and Polyclonal Antibodies Research

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 9922047
DOI: 10.3109/10428199809057616

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

All Patients with Persistent Polyclonal B Cell Lymphocytosis Present Bcl-2/Ig Gene RearrangementsPMID 9922047Read ↗

Persistent polyclonal B-cell lymphocytosis: further evidence for a genetic disorder associated with B-cell abnormalities.Semantic proximity Read ↗

B-cell signaling in persistent polyclonal B lymphocytosis (PPBL).Semantic proximity Read ↗

Prevalence and frequency of circulating t(14;18)‐MBR translocation carrying cells in healthy individualsSemantic proximity Read ↗

BCL2 translocation frequency rises with age in humans.Semantic proximity Read ↗

Persistent polyclonal B lymphocytosis: an expansion of cells showing IgVH gene mutations and phenotypic features of normal lymphocytes from the CD27+ marginal zone B-cell compartment.Semantic proximity Read ↗

The role of immunoglobulin translocations in the pathogenesis of B-cell malignanciesSemantic proximity Read ↗

Somatic point mutations in the translocated bcl-2 genes of non-Hodgkin's lymphomas and lymphocytic leukemias: implications for mechanisms of tumor progression.Semantic proximity Read ↗

Long-term clonal persistence and evolution of t(14;18)-bearing B cells in healthy individualsSemantic proximity Read ↗

Follicular lymphoma lacking the t(14;18)(q32;q21): identification of two disease subtypesSemantic proximity Read ↗

BCL2 translocations in leukemias of mature B cellsSemantic proximity Read ↗

Incidence and clinicobiologic characteristics of leukemic B-cell chronic lymphoproliferative disorders with more than one B-cell clone.Semantic proximity Read ↗

Bcl-2 initiates a new category of oncogenes: regulators of cell deathSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.