Article
Application of a PCR-mismatch technique to the BCL-2 gene: detection of point mutations in BCL-2 genes of malignancies with A t(14,18).
Leukemia - 1 Jan 1992
Tanaka S, Louie D, Kant J, Reed J C
Abstract excerpt
The ability to conveniently detect single-base mutations in the DNA of clinical material without prior knowledge of the mutant sequence remains a diagnostic challenge. Most techniques suffer from a lack of general applicability to all DNA sequences, poor sensitivity, requirement for RNA samples r...
Topics
- Amino Acid Sequence
- Chromosomes, Human, Pair 14
- Chromosomes, Human, Pair 18
- DNA Mutational Analysis
- Humans
- Leukemia, Lymphoid
- Lymphoma, Non-Hodgkin
- Molecular Sequence Data
- Mutation
- Polymerase Chain Reaction
- Translocation, Genetic