Article
Hot-spot p53 mutants interact specifically with two cellular proteins during progression of the cell cycle.
Molecular and cellular biology - 1 Oct 1994
Chen Y, Chen P L, Lee W H
Abstract excerpt
Inactivation of both alleles of the p53 gene is commonly found in human cancers. In contrast to mutations of the retinoblastoma gene, certain altered forms of p53 gain growth-promoting functions. To explore the mechanisms underlying this gain of function, we have identified two nuclear proteins,...
Topics
- ATP Binding Cassette Transporter, Subfamily B, Member 1
- Antigens, Viral, Tumor
- Cell Cycle
- Cell Nucleus
- Humans
- Mutation
- Nuclear Proteins
- Precipitin Tests
- Promoter Regions, Genetic
- Protein Binding
- Simian virus 40
- Transcriptional Activation
- Tumor Cells, Cultured
- Tumor Suppressor Protein p53