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Article

Point mutations in homology domain II modify the sensitivity of rat Nav1.8 sodium channels to the pyrethroid insecticide cismethrin.

Neurotoxicology - 1 Dec 2001

Soderlun D M, Lee S H

Abstract excerpt

Two point mutations in homology domain II of the housefly Vsscl voltage-sensitive sodium channel subunit, M918T and L1014F are associated with resistance to pyrethroid insecticides and reduce the pyrethroid sensitivity of Vsscl sodium channels expressed in Xenopus laevis oocytes. To assess the impact of these residues as determinants of pyrethroid sensitivity in another sequence context, we mutated the...

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PMID: 11829409
DOI: 10.1016/s0161-813x(01)00065-1

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Point mutations in homology domain II modify the sensitivity of rat Nav1.8 sodium channels to the pyrethroid insecticide cismethrin.PMID 11829409Read ↗

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The molecular interactions of pyrethroid insecticides with insect and mammalian sodium channels.Semantic proximity Read ↗

The L1014F Point Mutation in the House Fly Vssc1 Sodium Channel Confers Knockdown Resistance to PyrethroidsSemantic proximity Read ↗

Identification of amino acid residues in the insect sodium channel critical for pyrethroid binding.Semantic proximity Read ↗

Alanine to valine substitutions in the pore helix IIIP1 and linker-helix IIIL45 confer cockroach sodium channel resistance to DDT and pyrethroids.Semantic proximity Read ↗

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