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Article

On site of action of grayanotoxin in domain 4 segment 6 of rat skeletal muscle sodium channel.

FEBS letters - 7 Jan 2000

Kimura T, Kinoshita E, Yamaoka K, Yuki T, Yakehiro M, Seyama I

Abstract excerpt

Grayanotoxin I (GTX I) is a diterpenoid extracted from the family of Ericaceae that binds to Na(+) channels and causes persistent activation. We investigated the interaction of GTX I with the amino acid residues I1575, F1579 and Y1586 in transmembrane segment D4S6 of micro1. In F1579A, GTX shifted the threshold potential about 50 mV in the hyperpolarizing direction and modified Na(+) channels twice as efficiently...

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Source

Identifiers

PMID: 10620699
DOI: 10.1016/s0014-5793(99)01715-9

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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