The microI skeletal muscle sodium channel: mutation E403Q eliminates sensitivity to tetrodotoxin but not to mu-conotoxins GIIIA and GIIIB.

doi:10.1007/BF00234993

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Article

The microI skeletal muscle sodium channel: mutation E403Q eliminates sensitivity to tetrodotoxin but not to mu-conotoxins GIIIA and GIIIB.

The Journal of membrane biology - 1 Jan 1994

Stephan M M, Potts J F, Agnew W S

Abstract excerpt

Voltage-sensitive Na channels from nerve and muscle are blocked by the guanidinium toxins tetrodotoxin (TTX) and saxitoxin (STX). Mutagenesis studies of brain RII channels have shown that glutamate 387 (E387) is essential for current block by these toxins. We demonstrate here that mutation of glutamate 403 (E403) of the adult skeletal muscle microI channel (corresponding to E387 of RII) also prevents current...

Topics

Amino Acid Sequence
Animals
Base Sequence
Cells, Cultured
Conotoxins
DNA
Dose-Response Relationship, Drug
Glutamates
Glutamic Acid
Glutamine
Molecular Sequence Data

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Muscles

Mutation

Neuromuscular Blocking Agents

Oocytes

Peptides, Cyclic

Polymerase Chain Reaction

Rats

Source

Open in PubMed

Identifiers

PMID: 7911843
DOI: 10.1007/BF00234993

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7911843-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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