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Article

mu-Conotoxin PIIIA, a new peptide for discriminating among tetrodotoxin-sensitive Na channel subtypes.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 15 Jun 1998

Shon K J, Olivera B M, Watkins M, Jacobsen R B, Gray W R, Floresca C Z, Cruz L J, Hillyard D R, Brink A, Terlau H, Yoshikami D

Abstract excerpt

We report the characterization of a new sodium channel blocker, mu-conotoxin PIIIA(mu-PIIIA). The peptide has been synthesized chemically and its disulfide bridging pattern determined. The structure of the new peptide is: [sequence: see text] where Z = pyroglutamate and O = 4-trans-hydroxyproline. We demonstrate that Arginine-14 (Arg14) is a key residue; substitution by alanine significantly decreases affinity...

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PMID: 9614224
PMCID: PMC6792697

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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mu-Conotoxin PIIIA, a new peptide for discriminating among tetrodotoxin-sensitive Na channel subtypes.PMID 9614224Read ↗

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