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Article

Replication-defective viruses as vaccines and vaccine vectors.

Virology - 5 Jan 2006

Dudek Tim, Knipe David M

Abstract excerpt

The classical viral vaccine approaches using inactivated virus or live-attenuated virus have not been successful for some viruses, such as human immunodeficiency virus or herpes simplex virus. Therefore, new types of vaccines are needed to combat these infections. Replication-defective mutant viruses are defective for one or more functions that are essential for viral genome replication or synthesis and assembly...

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Identifiers

PMID: 16364753
DOI: 10.1016/j.virol.2005.09.020

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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