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Article

Replication-defective viruses modulate immune responses.

Journal of immunology (Baltimore, Md. : 1950) - 15 Oct 1991

Browning M J, Huneycutt B S, Huang A S, Reiss C S

Abstract excerpt

By immunizing inbred mice with purified replication-competent, defective virus particles, or an admixture of the two, differential effects on the cellular immune system have been uncovered. Defective virus, exemplified by the vesicular stomatitis virus (VSV) defective interfering particle (DI 0.33), induced in BALB/c mice low levels of proliferating, IL-2 secreting, and cytolytic Ag-specific T lymphocytes. This...

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PMID: 1655896

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