Replication-defective viruses modulate immune responses.

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Article

Replication-defective viruses modulate immune responses.

Journal of immunology (Baltimore, Md. : 1950) - 15 Oct 1991

Browning M J, Huneycutt B S, Huang A S, Reiss C S

Abstract excerpt

By immunizing inbred mice with purified replication-competent, defective virus particles, or an admixture of the two, differential effects on the cellular immune system have been uncovered. Defective virus, exemplified by the vesicular stomatitis virus (VSV) defective interfering particle (DI 0.33), induced in BALB/c mice low levels of proliferating, IL-2 secreting, and cytolytic Ag-specific T lymphocytes. This...

Topics

Animals
CD4 Antigens
CD8 Antigens
Cytotoxicity, Immunologic
Defective Viruses
Histocompatibility Antigens Class I
Histocompatibility Antigens Class II
Immunity, Cellular
Lymphocyte Activation
Mice
Mice, Inbred BALB C

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Phenotype

Spleen

T-Lymphocytes, Cytotoxic

Vesicular stomatitis Indiana virus

Viral Interference

Viral Proteins

Virus Replication

Source

Open in PubMed

Identifiers

PMID: 1655896

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1655896-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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