Article
An Engineered Herpesvirus Activates Dendritic Cells and Induces Protective Immunity.
Scientific reports - 2 Feb 2017
Ma Yijie, Chen Min, Jin Huali, Prabhakar Bellur S, Valyi-Nagy Tibor, He Bin
Abstract excerpt
Herpes simplex viruses (HSV) are human pathogens that switch between lytic and latent infection. While attenuated HSV is explored for vaccine, the underlying event remains poorly defined. Here we report that recombinant HSV-1 with a mutation in the γ134.5 protein, a virulence factor, stimulates dendritic cell (DC) maturation which is dependent on TANK-binding kinase 1 (TBK1). When exposed to CD11+ DCs, the mutant...
Topics
- Animals
- Antiviral Agents
- Cell Differentiation
- Cytokines
- Dendritic Cells
- Genetic Engineering
- Herpesviridae
- Herpesviridae Infections
- Immunity
- Interferon Regulatory Factor-3
- Mice, Inbred BALB C
- Mutation
- NF-kappa B
- Protein Serine-Threonine Kinases