Article
Primary malignant lymphoma of the brain: demonstration of the p53 gene mutations by PCR-SSCP analysis and immunohistochemistry.
Noshuyo byori = Brain tumor pathology - 1 Jan 1994
Koga H, Zhang S, Ichikawa T, Washiyama K, Kuroiwa T, Tanaka R, Kumanishi T
Abstract excerpt
Using PCR-SSCP and immunohistochemical analyses, mutations of the p53 tumor suppressor gene were examined in 5 cases of primary malignant lymphoma of the brain (diffuse large cell type). By PCR-SSCP and nucleotide analyses, p53 gene mutations were seen in 2 of the 5 cases. The mutation in one cas...
Topics
- Adult
- Aged
- Base Sequence
- Brain Neoplasms
- DNA, Neoplasm
- Female
- Genes, p53
- Humans
- Immunohistochemistry
- Lymphoma
- Male
- Middle Aged
- Molecular Sequence Data
- Mutation
- Polymerase Chain Reaction
- Polymorphism, Single-Stranded Conformational