Article
Molecular genetic analysis of primary lung cancer and cancer metastatic to the lung.
Anticancer research - 1 Jan 2000
Schreiber G, Pitterle D, Kim Y C, Bepler G
Abstract excerpt
The lung is a very common site for primary cancer and metastatic disease. Advances in tumor biology have provided insight into the sequence of genetic alterations leading to tumor and metastasis formation in the lung. In this review we address two genetic alterations, the dominant ras oncogene and the p53 tumor suppressor gene, which are commonly found in lung cancer and pulmonary metastases. We discuss their...
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