Article
Rejection of an IA+ variant line of FBL-3 leukemia by cytotoxic T lymphocytes with CD4+ and CD4-CD8- T cell receptor-alpha beta phenotypes generated in CD8-depleted C57BL/6 mice.
Journal of immunology (Baltimore, Md. : 1950) - 1 Jun 1993
Yoshimura A, Shiku H, Nakayama E
Abstract excerpt
FBL-3N is an MHC class II Ag+ variant line that was obtained spontaneously during maintenance of Friend virus-induced leukemia FBL-3 in an athymic C57BL/6 (B6) mouse. Inocula of FBL-3N, but not the parental FBL-3 tumor, regressed after initial growth in CD8-depleted, syngeneic B6 mice. The cellul...
Topics
- Animals
- Antibody Specificity
- Binding Sites, Antibody
- CD4 Antigens
- CD8 Antigens
- Clone Cells
- Cytotoxicity, Immunologic
- Flow Cytometry
- Friend murine leukemia virus
- Genetic Variation
- Graft Rejection
- Histocompatibility Antigens Class II
- Immunotherapy, Adoptive
- Leukemia, Erythroblastic, Acute
- Lymphocyte Depletion
- Mice
- Mice, Inbred C57BL
- Neoplasm Transplantation