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Article

MHC class II-deficient tumor cell lines with a defective expression of the class II transactivator.

International immunology - 1 May 2002

Naves Rodrigo, Lennon Ana Maria, Barbieri Giovanna, Reyes Lilian, Puga Gisella, Salas Laura, Deffrennes Virginie, Rosemblatt Mario, Fellous Marc, Charron Dominique, Alcaïde-Loridan Catherine, Bono Maria Rosa

Abstract excerpt

MHC class II expression defects have been evidenced in several human tumor cell lines originating from lung cancers or retinoblastoma. Accordingly, the mouse adenocarcinoma and fibrosarcoma cell lines, RAG and L(tk-), do not express I-A and I-E molecules even when treated with IFN-gamma. Here we show that fusion of both cell lines restores the inducible expression of MHC class II, thereby demonstrating that they...

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Source

Identifiers

PMID: 11978778
DOI: 10.1093/intimm/14.5.481

Genes

CIITA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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MHC class II-deficient tumor cell lines with a defective expression of the class II transactivator.PMID 11978778Read ↗

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