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Extracellular guanosine and GTP promote expression of differentiation markers and induce S‐phase cell‐cycle arrest in human SH‐SY5Y neuroblastoma cells

6 Dec 2008

Abstract excerpt

SH-SY5Y neuroblastoma cells, a model for studying neuronal differentiation, are able to differentiate into either cholinergic or dopaminergic/adrenergic phenotypes depending on media conditions. Using this system, we asked whether guanosine (Guo) or guanosine-5'-triphosphate (GTP) are able to drive differentiation towards one particular phenotype. Differentiation was determined by evaluating the frequency of...

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PMID: 19111604
DOI: 10.1016/j.ijdevneu.2008.11.007

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