Article
Sub-micromolar concentrations of retinoic acid induce morphological and functional neuronal phenotypes in SK-N-SH neuroblastoma cells.
In vitro cellular & developmental biology. Animal - 1 Oct 2017
Harasym Emily, McAndrew Nicole, Gomez George
Abstract excerpt
Neuroblastoma cells are neural crest derivatives that can differentiate into neuron-like cells in response to exogenous agents, and are known to be particularly sensitive to retinoic acid. The spectrum of neuroblastoma responses, ranging from proliferation, migration, differentiation, or apoptosis, is difficult to predict due to the heterogeneity of these tumors and to the broad effective range of retinoic acid....
Topics
- Cell Differentiation
- Cell Line, Tumor
- Cell Proliferation
- Cell Shape
- Humans
- Intermediate Filaments
- Neurites
- Neuroblastoma
- Neurogenesis
- Neurons
- Phenotype
- Receptors, Retinoic Acid
- Tretinoin
- Up-Regulation