Article

An immature subset of neuroblastoma cells synthesizes retinoic acid and depends on this metabolite

2021-05-18

Abstract excerpt

Neuroblastoma is a pediatric tumor of the adrenergic sympathetic lineage. Most high risk neuroblastoma go in complete clinical remission by chemotherapy, which is subsequently complemented by retinoic acid (RA) maintenance therapy. However, by unresolved mechanisms most tumors ultimately relapse as therapy-resistant disease. Neuroblastoma cell lines were recently found to include, besides lineage committed adrener...

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Literature Corpus work: 033a9856-9222-5df1-8fca-021ce7a566db
DOI: 10.1101/2021.05.18.444639

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