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Recurrent chromosomal abnormalities in hepatocellular carcinoma detected by comparative genomic hybridization

1 Jan 1997

Abstract excerpt

Comparative genomic hybridization (CGH) was used to evaluate and map genomic aberrations in 50 hepatocellular carcinomas (HCCs) from patients chronically infected with hepatitis B virus (HBV). CGH clearly detected nonrandom genomic imbalances. Losses were most prevalent on chromosome regions 4q (70%), 8p (65%), 16q (54%), 17p (51%), 13q and 6q (37% each), and lp (30%). The most frequent gains occurred on 8q...

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PMID: 8993981
DOI: 10.1002/(sici)1098-2264(199701)18:1<59::aid-gcc7>3.0.co;2-0

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