Article
Avian cells expressing the murine Mx1 protein are resistant to influenza virus infection.
Virology - 1 Feb 1991
Garber E A, Chute H T, Condra J H, Gotlib L, Colonno R J, Smith R G
Abstract excerpt
The cDNA encoding the murine Mx1 protein, a mediator of resistance to influenza virus, was inserted into a replication-competent avian retroviral vector in either the sense (referred to as Mx+) or the antisense (referred to as Mx-) orientation relative to the viral structural genes. Both vectors...
Topics
- Animals
- Antiviral Agents
- Cell Line
- Cells, Cultured
- Chick Embryo
- Fibroblasts
- Fluorescent Antibody Technique
- GTP-Binding Proteins
- Genetic Predisposition to Disease
- Immunoblotting
- Influenza A virus
- Mice
- Mice, Inbred Strains
- Myxovirus Resistance Proteins
- Proteins
- Transfection
- Viral Plaque Assay