Article
Mechanism of human MxA protein action: variants with changed antiviral properties.
The EMBO journal - 1 Apr 1992
Zürcher T, Pavlovic J, Staeheli P
Abstract excerpt
Cells respond to treatment with interferons by synthesizing several induced proteins, including one or more structurally related proteins collectively called Mx. Nuclear and cytoplasmic forms of Mx have been described, some of which inhibit virus replication. Human MxA is a cytoplasmic protein th...
Topics
- 3T3 Cells
- Amino Acid Sequence
- Animals
- Antiviral Agents
- Arginine
- Base Sequence
- GTP-Binding Proteins
- Genetic Variation
- Genome, Viral
- Humans
- Influenza A virus
- Mice
- Molecular Sequence Data
- Mutagenesis, Site-Directed
- Myxovirus Resistance Proteins
- Oligodeoxyribonucleotides
- Open Reading Frames
- Proteins