Sodium butyrate inhibits myogenesis by interfering with the transcriptional activation function of MyoD and myogenin.

doi:10.1128/mcb.12.11.5123-5130.1992

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Article

Sodium butyrate inhibits myogenesis by interfering with the transcriptional activation function of MyoD and myogenin.

Molecular and cellular biology - 1 Nov 1992

Johnston L A, Tapscott S J, Eisen H

Abstract excerpt

Sodium butyrate reversibly inhibits muscle differentiation and blocks the expression of many muscle-specific genes in both proliferating myoblasts and differentiated myotubes. We investigated the role of the basic helix-loop-helix (bHLH) myogenic determinator proteins MyoD and myogenin in this inhibition. Our data suggest that both MyoD and myogenin are not able to function as transcriptional activators in the...

Topics

Base Sequence
Butyrates
Butyric Acid
Cell Differentiation
Cell Line
DNA
Gene Expression Regulation
Molecular Sequence Data
Muscle Proteins
Muscles
Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

MyoD Protein

Myogenin

Organ Specificity

Protein Binding

Transcription Factors

Transcription, Genetic

Source

Open in PubMed Open full text

Identifiers

PMID: 1328872
DOI: 10.1128/mcb.12.11.5123-5130.1992
PMCID: PMC360446

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1328872-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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