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Article

Smad7 promotes and enhances skeletal muscle differentiation.

Molecular and cellular biology - 1 Aug 2006

Kollias Helen D, Perry Robert L S, Miyake Tetsuaki, Aziz Arif, McDermott John C

Abstract excerpt

Transforming growth factor beta1 (TGF-beta1) and myostatin signaling, mediated by the same Smad downstream effectors, potently repress skeletal muscle cell differentiation. Smad7 inhibits these cytokine signaling pathways. The role of Smad7 during skeletal muscle cell differentiation was assessed. In these studies, we document that increased expression of Smad7 abrogates myostatin- but not TGF-beta1-mediated...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 16880533
DOI: 10.1128/MCB.00384-06
PMCID: PMC1592807

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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