Negative control of the helix-loop-helix family of myogenic regulators in the NFB mutant.

doi:10.1016/0092-8674(90)90014-6

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Article

Negative control of the helix-loop-helix family of myogenic regulators in the NFB mutant.

Cell - 10 Aug 1990

Peterson C A, Gordon H, Hall Z W, Paterson B M, Blau H M

Abstract excerpt

We have characterized a nondifferentiating mouse muscle cell line, NFB, that represses the activity of the helix-loop-helix (HLH) family of myogenic regulators, yet expresses sarcomeric actins. The NFB MyoD gene is silent, but can be activated upon transfection of a long terminal region-controlle...

Topics

Actins
Animals
Blotting, Northern
Blotting, Southern
Cell Differentiation
Cell Line
DNA
Ethyl Methanesulfonate
Fluorescent Antibody Technique
Genes, Regulator
Mice
Muscle Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Muscles

Mutation

MyoD Protein

Phenotype

RNA

RNA, Messenger

Source

Open in PubMed

Identifiers

PMID: 1696180
DOI: 10.1016/0092-8674(90)90014-6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-1696180-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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