Natural Vitamin D 3 Response Elements Formed by Inverted Palindromes: Polarity-Directed Ligand Sensitivity of Vitamin D 3 Receptor-Retinoid X Receptor Heterodimer-Mediated Transactivation

Abstract excerpt

VDR, the nuclear receptor for 1,25-dihydroxyvitamin D3 (VD), is a member of the superfamily of nuclear hormone receptors and controls multiple aspects of homeostasis, cell growth, and differentiation. VDR can function as a homodimer, but heterodimerization with the retinoid X receptor (RXR), retinoic acid receptor, or thyroid hormone receptor increases its affinity for response elements in the promoter of target...

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