Article
Oligomeric binding of T3 receptor is required for maximal T3 response.
The Journal of biological chemistry - 15 Oct 1991
Williams G R, Harney J W, Forman B M, Samuels H H, Brent G A
Abstract excerpt
Receptors in the thyroid-steroid hormone superfamily bind preferentially as dimers to palindromic response elements containing two hexameric half-sites. The 23-base pair rat growth hormone (rGH) T3 response element (T3RE), however, contains three hexameric binding domains, all of which are required for maximal T3 response. We examined the binding of purified T3 receptor alpha (T3R alpha), overexpressed in...
Topics
- Animals
- Binding Sites
- Chickens
- Electrophoresis, Polyacrylamide Gel
- Escherichia coli
- Gene Expression
- Genes, Bacterial
- Growth Substances
- Male
- Mutation
- Plasmids
- Rats