Mosaic and polymorphic imprinting of the WT1 gene in humans.

doi:10.1038/ng0394-305

Back to search

Article

Mosaic and polymorphic imprinting of the WT1 gene in humans.

Nature genetics - 1 Mar 1994

Jinno Y, Yun K, Nishiwaki K, Kubota T, Ogawa O, Reeve A E, Niikawa N

Abstract excerpt

We have examined the imprinting of the Wilms' tumour suppressor gene (WT1) in human tissues. We confirm that WT1 is biallelically expressed in the kidney, however, in five of nine preterm placentae WT1 was expressed largely or exclusively from the maternal allele. Monoallelic expression of WT1 wa...

Topics

Alleles
Base Sequence
DNA Primers
Female
Gene Expression
Genes, Wilms Tumor
Humans
Male
Molecular Sequence Data
Mosaicism
Placenta
Polymorphism, Genetic
Pregnancy
Tissue Distribution

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.