Article
Mosaic and polymorphic imprinting of the WT1 gene in humans.
Nature genetics - 1 Mar 1994
Jinno Y, Yun K, Nishiwaki K, Kubota T, Ogawa O, Reeve A E, Niikawa N
Abstract excerpt
We have examined the imprinting of the Wilms' tumour suppressor gene (WT1) in human tissues. We confirm that WT1 is biallelically expressed in the kidney, however, in five of nine preterm placentae WT1 was expressed largely or exclusively from the maternal allele. Monoallelic expression of WT1 was also found in two fetal brains. These data demonstrate that WT1 can undergo tissue specific imprinting. Furthermore,...
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