Article
The rate and character of spontaneous mutation in an RNA virus.
Genetics - 1 Dec 2002
Malpica José M, Fraile Aurora, Moreno Ignacio, Obies Clara I, Drake John W, García-Arenal Fernando
Abstract excerpt
Estimates of spontaneous mutation rates for RNA viruses are few and uncertain, most notably due to their dependence on tiny mutation reporter sequences that may not well represent the whole genome. We report here an estimate of the spontaneous mutation rate of tobacco mosaic virus using an 804-base cognate mutational target, the viral MP gene that encodes the movement protein (MP). Selection against newly arising...
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