Article
Mutations in a conserved enteroviral RNA oligonucleotide sequence affect positive strand viral RNA synthesis.
Archives of virology - 1 Jan 2000
Willian S, Tracy S, Chapman N, Leser S, Romero J, Shapiro B, Currey K
Abstract excerpt
We showed earlier that a transition mutation U234C, located within the completely conserved 5 nucleotide (nt) tract 5'-CGUUA (nt232-236) in the 5' non-translated region (NTR) of the coxsackievirus B3 (CVB3) genome, attenuated CVB3 cardiovirulence in mice. To further explore the role of the sequen...
Topics
- 5' Untranslated Regions
- Animals
- Base Sequence
- Cell Line
- Conserved Sequence
- Coxsackievirus Infections
- Enterovirus B, Human
- Humans
- Male
- Mice
- Mice, Inbred C3H
- Mutation
- Oligonucleotides
- Protein Biosynthesis
- RNA, Viral
- Temperature
- Transfection
- Virus Replication