Article
Recombinant human bone morphogenetic protein-2 induces osteoblastic differentiation in W-20-17 stromal cells.
Endocrinology - 1 Mar 1992
Thies R S, Bauduy M, Ashton B A, Kurtzberg L, Wozney J M, Rosen V
Abstract excerpt
To better understand the in vivo bone-inductive properties of recombinant human (rh) BMP-2, we examined the ability of the protein to alter the phenotype of a bone marrow stromal cell line. W-20-17. rhBMP-2 increased alkaline phosphatase activity in W-20-17 cells in a dose-responsive manner in the absence of an effect on proliferation. The induction of alkaline phosphatase activity was not apparent until 12 h...
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