Mutations of ras genes distinguish a subset of non-small-cell lung cancer cell lines from small-cell lung cancer cell lines.

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Article

Mutations of ras genes distinguish a subset of non-small-cell lung cancer cell lines from small-cell lung cancer cell lines.

Oncogene - 1 Aug 1991

Mitsudomi T, Viallet J, Mulshine J L, Linnoila R I, Minna J D, Gazdar A F

Abstract excerpt

We screened a panel of 103 human lung cancer cell lines for the presence of point mutations at codons 12, 13 or 61 of the human K-, H- and N-ras genes, using restriction fragment length polymorphisms (RFLP), created through mismatched primers during polymerase chain reaction (PCR) of genomic DNA. We found ras mutations in 22/61 (36%) non-small-cell lung cancer (NSCLC) cell lines, predominantly in K-ras codon 12....

Topics

Alleles
Base Sequence
Carcinoma, Non-Small-Cell Lung
Carcinoma, Small Cell
Codon
DNA, Neoplasm
Diagnosis, Differential
Female
Genes, ras
Humans
Lung Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Male

Molecular Sequence Data

Mutation

Polymerase Chain Reaction

Polymorphism, Restriction Fragment Length

Tumor Cells, Cultured

Source

Open in PubMed

Identifiers

PMID: 1679529

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1679529-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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