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Article

Neutralization-resistant variants of a neurotropic coronavirus are generated by deletions within the amino-terminal half of the spike glycoprotein.

Journal of virology - 1 Feb 1990

Gallagher T M, Parker S E, Buchmeier M J

Abstract excerpt

Neuroattenuated variants of mouse hepatitis virus type 4 (MHV-4) selected for resistance to neutralizing monoclonal antibodies (R.G. Dalziel, P.W. Lampert, P. J. Talbot, and M. J. Buchmeier, J. Virol. 59:463-471, 1986) were found to harbor large deletions in both mRNA 3 and its protein product, the 180-kilodalton viron spike (S) glycoprotein. By using antipeptide antibodies directed against selected portions of...

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Identifiers

PMID: 1688627
DOI: 10.1128/JVI.64.2.731-741.1990
PMCID: PMC249167

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