Neutralization-resistant variants of a neurotropic coronavirus are generated by deletions within the amino-terminal half of the spike glycoprotein.

doi:10.1128/JVI.64.2.731-741.1990

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Article

Neutralization-resistant variants of a neurotropic coronavirus are generated by deletions within the amino-terminal half of the spike glycoprotein.

Journal of virology - 1 Feb 1990

Gallagher T M, Parker S E, Buchmeier M J

Abstract excerpt

Neuroattenuated variants of mouse hepatitis virus type 4 (MHV-4) selected for resistance to neutralizing monoclonal antibodies (R.G. Dalziel, P.W. Lampert, P. J. Talbot, and M. J. Buchmeier, J. Virol. 59:463-471, 1986) were found to harbor large deletions in both mRNA 3 and its protein product, the 180-kilodalton viron spike (S) glycoprotein. By using antipeptide antibodies directed against selected portions of...

Topics

Amino Acid Sequence
Animals
Antibodies, Monoclonal
Blotting, Northern
Blotting, Western
Cell Line
Chromosome Deletion
Epitopes
Genes, Viral
Genetic Variation
Kinetics

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice

Mice, Inbred BALB C

Molecular Sequence Data

Murine hepatitis virus

Mutation

Neutralization Tests

RNA, Viral

Source

Open in PubMed Open full text

Identifiers

PMID: 1688627
DOI: 10.1128/JVI.64.2.731-741.1990
PMCID: PMC249167

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1688627-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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