Article
Evolution of mouse hepatitis virus: detection and characterization of spike deletion variants during persistent infection.
Journal of virology - 1 Apr 1997
Rowe C L, Baker S C, Nathan M J, Fleming J O
Abstract excerpt
High-frequency RNA recombination has been proposed as an important mechanism for generating viral deletion variants of murine coronavirus. Indeed, a number of variants with deletions in the spike glycoprotein have been isolated from persistently infected animals. However, the significance of gene...
Topics
- Animals
- Brain
- Cell Line
- Coronavirus Infections
- Evolution, Molecular
- Gene Deletion
- Genetic Variation
- Male
- Membrane Glycoproteins
- Mice
- Mice, Inbred C57BL
- Murine hepatitis virus
- Nervous System Diseases
- Spike Glycoprotein, Coronavirus
- Spinal Cord
- Time Factors
- Viral Envelope Proteins
- Virus Latency