Article
Evolution of mouse hepatitis virus: detection and characterization of spike deletion variants during persistent infection.
Journal of virology - 1 Apr 1997
Rowe C L, Baker S C, Nathan M J, Fleming J O
Abstract excerpt
High-frequency RNA recombination has been proposed as an important mechanism for generating viral deletion variants of murine coronavirus. Indeed, a number of variants with deletions in the spike glycoprotein have been isolated from persistently infected animals. However, the significance of generating and potentially accumulating deletion variants in the persisting viral RNA population is unclear. To study this...
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