Article
Biochemical properties of MutT2 proteins from Mycobacterium tuberculosis and M. smegmatis and their contrasting antimutator roles in Escherichia coli.
Journal of bacteriology - 1 Apr 2013
Sang Pau Biak, Varshney Umesh
Abstract excerpt
Mycobacterium tuberculosis, the causative agent of tuberculosis, is at increased risk of accumulating damaged guanine nucleotides such as 8-oxo-dGTP and 8-oxo-GTP because of its residency in the oxidative environment of the host macrophages. By hydrolyzing the oxidized guanine nucleotides before their incorporation into nucleic acids, MutT proteins play a critical role in allowing organisms to avoid their...
Topics
- Amino Acid Sequence
- Bacterial Proteins
- Deoxycytosine Nucleotides
- Deoxyguanine Nucleotides
- Escherichia coli
- Guanosine Triphosphate
- Kinetics
- Molecular Sequence Data
- Mutation
- Mycobacterium smegmatis
- Mycobacterium tuberculosis
- Oxidation-Reduction
- Recombinant Proteins
- Sequence Homology, Amino Acid