Article
Establishment of distinct MyoD, E2A, and twist DNA binding specificities by different basic region-DNA conformations.
Molecular and cellular biology - 1 Jan 2000
Kophengnavong T, Michnowicz J E, Blackwell T K
Abstract excerpt
Basic helix-loop-helix (bHLH) proteins perform a wide variety of biological functions. Most bHLH proteins recognize the consensus DNA sequence CAN NTG (the E-box consensus sequence is underlined) but acquire further functional specificity by preferring distinct internal and flanking bases. In addition, induction of myogenesis by MyoD-related bHLH proteins depends on myogenic basic region (BR) and BR-HLH junction...
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