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Article

Myogenin resides in the nucleus and acquires high affinity for a conserved enhancer element on heterodimerization.

Genes & development - 1 Apr 1990

Brennan T J, Olson E N

Abstract excerpt

Myogenin is a member of a family of muscle-specific factors that can activate the muscle differentiation program in nonmyogenin cells. Using antibodies directed against unique domains of myogenin, we show in the present study that myogenin resides in the nucleus of differentiated muscle cells. Myogenin translated in vitro does not exhibit detectable DNA binding activity; however, when dimerized with the...

Topics

Base Sequence
Cell Line
Cell Nucleus
Creatine Kinase
DNA
DNA-Binding Proteins
Enhancer Elements, Genetic
Fluorescent Antibody Technique
Methylation
Molecular Sequence Data
Muscle Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Muscles

Mutation

Myogenin

Precipitin Tests

Transcription Factors

Source

Identifiers

PMID: 2163343
DOI: 10.1101/gad.4.4.582

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2163343-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Myogenin resides in the nucleus and acquires high affinity for a conserved enhancer element on heterodimerization.PMID 2163343Read ↗

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