Article
Visualizing corticotropin-releasing hormone receptor type 1 expression and neuronal connectivities in the mouse using a novel multifunctional allele.
The Journal of comparative neurology - 1 Oct 2012
Kühne Claudia, Puk Oliver, Graw Jochen, Hrabě de Angelis Martin, Schütz Günther, Wurst Wolfgang, Deussing Jan M
Abstract excerpt
The corticotropin-releasing hormone (CRH) and its type 1 receptor (CRHR1) play a central role in coordinating the endocrine, autonomic, and behavioral responses to stress. A prerequisite to functionally dissect the complexity of the CRH/CRHR1 system is to unravel the identity of CRHR1-expressing neurons and their connectivities. Therefore, we used a knockin approach to genetically label CRHR1-expressing cells...
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