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Article

A mouse-based strategy for cyclophosphamide pharmacogenomic discovery.

Journal of applied physiology (Bethesda, Md. : 1985) - 1 Oct 2003

Watters James W, Kloss Ellen F, Link Daniel C, Graubert Timothy A, McLeod Howard L

Abstract excerpt

Genome-wide mapping approaches are needed to more fully understand the genetic basis of chemotherapy response. Because of technical and ethical limitations, cancer pharmacogenomics has not yet benefited from traditional robust familial genetic strategies. We have therefore explored the use of the inbred mouse as a genetic model system in which to study response to the cytotoxic agent cyclophosphamide. Multiple...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 12970373
DOI: 10.1152/japplphysiol.00214.2003

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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