Article
Mouse population-guided resequencing reveals that variants in CD44 contribute to acetaminophen-induced liver injury in humans.
Genome research - 1 Sept 2009
Harrill Alison H, Watkins Paul B, Su Stephen, Ross Pamela K, Harbourt David E, Stylianou Ioannis M, Boorman Gary A, Russo Mark W, Sackler Richard S, Harris Stephen C, Smith Philip C, Tennant Raymond, Bogue Molly, Paigen Kenneth, Harris Christopher, Contractor Tanupriya, Wiltshire Timothy, Rusyn Ivan, Threadgill David W
Abstract excerpt
Interindividual variability in response to chemicals and drugs is a common regulatory concern. It is assumed that xenobiotic-induced adverse reactions have a strong genetic basis, but many mechanism-based investigations have not been successful in identifying susceptible individuals. While recent advances in pharmacogenetics of adverse drug reactions show promise, the small size of the populations susceptible to...
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