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Article

Mouse Population-Based Approaches to Investigate Adverse Drug Reactions.

Drug metabolism and disposition: the biological fate of chemicals - 1 Nov 2018

Mosedale Merrie

Abstract excerpt

Genetic variation is now recognized as a key factor in the toxicity of pharmaceutical agents. However, genetic diversity is not present in standard nonclinical toxicology models, and small clinical studies (phase I/II) may not include enough subjects to identify toxicity liabilities associated with less common susceptibility factors. As a result, many drugs pass through preclinical and early clinical studies...

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PMID: 30045843
DOI: 10.1124/dmd.118.082834

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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