Article
In vitro and in vivo mouse models for pharmacogenetic studies.
Methods in molecular biology (Clifton, N.J.) - 1 Jan 2013
Frick Amber, Suzuki Oscar, Butz Natasha, Chan Emmanuel, Wiltshire Tim
Abstract excerpt
The identification of causative genes underlying biomedically relevant phenotypes, particularly complex multigenic traits, is of vital interest to modern medicine. Using genome-wide association analysis, many studies have successfully identified thousands of loci (called quantitative trait loci or QTL), some of these associating with drug response phenotypes. However, the determination and validation of putative...
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