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Article

Acyclovir is phosphorylated by the human cytomegalovirus UL97 protein.

Antimicrobial agents and chemotherapy - 1 Aug 1999

Talarico C L, Burnette T C, Miller W H, Smith S L, Davis M G, Stanat S C, Ng T I, He Z, Coen D M, Roizman B, Biron K K

Abstract excerpt

Acyclovir (ACV) has shown efficacy in the prophylactic suppression of human cytomegalovirus (HCMV) reactivation in immunocompromised renal transplant patients without the toxicity associated with ganciclovir (GCV). The HCMV UL97 gene product, a protein kinase, is responsible for the phosphorylation of GCV in HCMV-infected cells. This report provides evidence for the phosphorylation of ACV by UL97. Anabolism...

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Source

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Identifiers

PMID: 10428917
DOI: 10.1128/AAC.43.8.1941
PMCID: PMC89395

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Acyclovir is phosphorylated by the human cytomegalovirus UL97 protein.PMID 10428917Read ↗

Genetic analysis of a ganciclovir-resistant human cytomegalovirus mutant.Semantic proximity Read ↗

Human Cytomegalovirus Protein Kinase UL97 Forms a Complex with the Tegument Phosphoprotein pp65Semantic proximity Read ↗

A Recombinant Human Cytomegalovirus with a Large Deletion in <i>UL97</i> Has a Severe Replication DeficiencySemantic proximity Read ↗

Cytomegalovirus UL97 mutations in the era of ganciclovir and maribavirSemantic proximity Read ↗

Cyclin-Dependent Kinase-Like Function Is Shared by the Beta- and Gamma- Subset of the Conserved Herpesvirus Protein KinasesSemantic proximity Read ↗

Amino acids of conserved kinase motifs of cytomegalovirus protein UL97 are essential for autophosphorylation.Semantic proximity Read ↗

Inhibitors of human cytomegalovirus replication drastically reduce the activity of the viral protein kinase pUL97.Semantic proximity Read ↗

Mutations in the UL97 ORF of ganciclovir-resistant clinical cytomegalovirus isolates differentially affect GCV phosphorylation as determined in a recombinant vaccinia virus systemSemantic proximity Read ↗

Analysis of the UL97 phosphotransferase coding sequence in clinical cytomegalovirus isolates and identification of mutations conferring ganciclovir resistance.Semantic proximity Read ↗

A nine-codon deletion mutation in the cytomegalovirus UL97 phosphotransferase gene confers resistance to ganciclovir.Semantic proximity Read ↗

GCV resistance due to the mutation A594P in the cytomegalovirus protein UL97 is partially reconstituted by a second mutation at D605E.Semantic proximity Read ↗

A three-nucleotide deletion in the UL97 open reading frame is responsible for the ganciclovir resistance of a human cytomegalovirus clinical isolateSemantic proximity Read ↗

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