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Article

Juxtaparanodal clustering of Shaker-like K+ channels in myelinated axons depends on Caspr2 and TAG-1.

The Journal of cell biology - 15 Sept 2003

Poliak Sebastian, Salomon Daniela, Elhanany Hadas, Sabanay Helena, Kiernan Brent, Pevny Larysa, Stewart Colin L, Xu Xiaorong, Chiu Shing-Yan, Shrager Peter, Furley Andrew J W, Peles Elior

Abstract excerpt

In myelinated axons, K+ channels are concealed under the myelin sheath in the juxtaparanodal region, where they are associated with Caspr2, a member of the neurexin superfamily. Deletion of Caspr2 in mice by gene targeting revealed that it is required to maintain K+ channels at this location. Furthermore, we show that the localization of Caspr2 and clustering of K+ channels at the juxtaparanodal region depends on...

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Share to Cell Adhesion Molecules, Neuronal

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Nerve Fibers, Myelinated

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Source

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Identifiers

PMID: 12963709
DOI: 10.1083/jcb.200305018
PMCID: PMC2172860

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Juxtaparanodal clustering of Shaker-like K+ channels in myelinated axons depends on Caspr2 and TAG-1.PMID 12963709Read ↗

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