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Article

Multiple molecular interactions determine the clustering of Caspr2 and Kv1 channels in myelinated axons.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 24 Dec 2008

Horresh Ido, Poliak Sebastian, Grant Seth, Bredt David, Rasband Matthew N, Peles Elior

Abstract excerpt

Clustering of Kv1 channels at the juxtaparanodal region (JXP) in myelinated axons depends on their association with the Caspr2/TAG-1 adhesion complex. The interaction between these channels and Caspr2 was suggested to depend on PDZ (PSD-95/Discs large/zona occludens-1) scaffolding proteins. Here, we show that at a subset of the JXP, PSD-93 colocalizes with Caspr2, K(+) channels and its related protein...

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Share to Cell Adhesion Molecules, Neuronal
Share to Disks Large Homolog 4 Protein

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Guanylate Kinases

Share to Hemagglutinins

Share to Nerve Fibers, Myelinated

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Share to Shaker Superfamily of Potassium Channels

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Source

Open in PubMed Open full text

Identifiers

PMID: 19109503
DOI: 10.1523/JNEUROSCI.3398-08.2008
PMCID: PMC2859216

Genes

PSD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Multiple molecular interactions determine the clustering of Caspr2 and Kv1 channels in myelinated axons.PMID 19109503Read ↗

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