Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Association of TAG-1 with Caspr2 is essential for the molecular organization of juxtaparanodal regions of myelinated fibers.

The Journal of cell biology - 15 Sept 2003

Traka Maria, Goutebroze Laurence, Denisenko Natalia, Bessa Maria, Nifli Artemisia, Havaki Sophia, Iwakura Yoichiro, Fukamauchi Fumihiko, Watanabe Kazutada, Soliven Betty, Girault Jean-Antoine, Karagogeos Domna

Abstract excerpt

Myelination results in a highly segregated distribution of axonal membrane proteins at nodes of Ranvier. Here, we show the role in this process of TAG-1, a glycosyl-phosphatidyl-inositol-anchored cell adhesion molecule. In the absence of TAG-1, axonal Caspr2 did not accumulate at juxtaparanodes,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Adhesion Molecules, Neuronal
Share to Macromolecular Substances

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Nerve Fibers, Myelinated

Share to Nervous System

Share to Neural Conduction

Share to Neuroglia

Share to Neuropeptides

Share to Shaker Superfamily of Potassium Channels

Source

Open in PubMed Open full text

Identifiers

PMID: 12975355
DOI: 10.1083/jcb.200305078
PMCID: PMC2172849

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-12975355-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Association of TAG-1 with Caspr2 is essential for the molecular organization of juxtaparanodal regions of myelinated fibers.PMID 12975355Read ↗

Juxtaparanodal clustering of Shaker-like K+ channels in myelinated axons depends on Caspr2 and TAG-1.Semantic proximity Read ↗

The expression of TAG-1 in glial cells is sufficient for the formation of the juxtaparanodal complex and the phenotypic rescue of tag-1 homozygous mutants in the CNS.Semantic proximity Read ↗

Organization of myelinated axons by Caspr and Caspr2 requires the cytoskeletal adapter protein 4.1B.Semantic proximity Read ↗

Nodes of Ranvier in health and diseaseSemantic proximity Read ↗

Multiple molecular interactions determine the clustering of Caspr2 and Kv1 channels in myelinated axons.Semantic proximity Read ↗

Contactin-1 regulates myelination and nodal/paranodal domain organization in the central nervous system.Semantic proximity Read ↗

Contactin-2/TAG-1, active on the front line for three decadesSemantic proximity Read ↗

Protein 4.1B contributes to the organization of peripheral myelinated axons.Semantic proximity Read ↗

Neuronal functions of adaptor complexes involved in protein sorting.Semantic proximity Read ↗

Tetraspanin Proteins Mediate Cellular Penetration, Invasion, and Fusion Events and Define a Novel Type of Membrane MicrodomainSemantic proximity Read ↗

Glial and neuronal isoforms of Neurofascin have distinct roles in the assembly of nodes of Ranvier in the central nervous system.Semantic proximity Read ↗

Axonal domain disorganization in Caspr1 and Caspr2 mutant myelinated axons affects neuromuscular junction integrity, leading to muscle atrophy.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.