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Article

Organization of myelinated axons by Caspr and Caspr2 requires the cytoskeletal adapter protein 4.1B.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 17 Feb 2010

Horresh Ido, Bar Vered, Kissil Joseph L, Peles Elior

Abstract excerpt

Caspr and Caspr2 regulate the formation of distinct axonal domains around the nodes of Ranvier. Caspr is required for the generation of a membrane barrier at the paranodal junction (PNJ), whereas Caspr2 serves as a membrane scaffold that clusters Kv1 channels at the juxtaparanodal region (JXP). Both Caspr and Caspr2 interact with protein 4.1B, which may link the paranodal and juxtaparanodal adhesion complexes to...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Kv1.1 Potassium Channel

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Source

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Identifiers

PMID: 20164332
DOI: 10.1523/JNEUROSCI.5225-09.2010
PMCID: PMC2836844

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